| 2022-06-06 20:30:00Mon, June 6, 2022 | FYU Family vs Markham Machine | 20:30:00Postponed | - | Regular Season | |
| 2022-06-06 21:45:00Mon, June 6, 2022 | Markham Machine vs Cereal Killers | 21:45:00Canceled | 14 - 0 | Regular Season | |
| 2022-06-15 22:05:00Wed, June 15, 2022 | Eb.O vs Markham Machine | 22:05:0010:05 PM | 23 - 0 | Regular Season | |
| 2022-06-22 22:05:00Wed, June 22, 2022 | Markham Machine vs Greyhounds | 22:05:0010:05 PM | 0 - 19 | Regular Season | |
| 2022-07-04 22:05:00Mon, July 4, 2022 | WolfPack vs Markham Machine | 22:05:0010:05 PM | 32 - 18 | Regular Season | |
| 2022-07-13 21:00:00Wed, July 13, 2022 | Cobras vs Markham Machine | 21:00:009:00 PM | 33 - 0 | Regular Season | |
| 2022-07-18 22:05:00Mon, July 18, 2022 | Markham Machine vs Mustangs | 22:05:0010:05 PM | 13 - 9 | Regular Season | |
| 2022-07-20 22:05:00Wed, July 20, 2022 | FYU Family vs Markham Machine | 22:05:0010:05 PM | 7 - 14 | Regular Season | |
| 2022-07-27 22:05:00Wed, July 27, 2022 | Warriors vs Markham Machine | 22:05:0010:05 PM | 14 - 6 | Regular Season | |
| 2022-08-03 22:05:00Wed, August 3, 2022 | Markham Machine vs Assassins | 22:05:0010:05 PM | 7 - 25 | Regular Season | |
| 2022-08-15 21:00:00Mon, August 15, 2022 | Toronto Generals vs Markham Machine | 21:00:009:00 PM | 0 - 6 | 2022, Regular Season | |
